Cold atmospheric plasma (cold plasma for short) is already proving its effectiveness in the treatment of chronic and acute wounds by reducing microorganisms without contact or chemicals. Viruses, fungi and bacteria, including multi-resistant pathogens (MRE), are efficiently and sustainably destroyed by cold plasma. It therefore made sense to extend this active principle to other areas of application, such as the disinfection of objects and surfaces. With a prototype called “tpTop”, a handy and mobile cold plasma decontamination device with aerosol support, it has now been possible to deactivate up to 99.9% of microorganisms within a few seconds of treatment. This opens up new application possibilities for the future, such as the fast and sustainable disinfection of surfaces of all kinds.