Medical technology

Wound treatment

• The world's first and largest clinical trial with cold plasma for the treatment of chronic wounds and skin diseases was conducted under the leadership of the Max Planck Institute for Extraterrestrial Physics together with the public hospital Klinikum München, the University Hospital Regensburg, Adtec Ltd. and terraplasma GmbH.

• The clinical trial involved 379 patients and >3,000 plasma treatments for chronic/acute wounds and skin diseases (herpes zoster, Hailey-Hailey, atopiceczema, etc.). The results are as follows:

- Significant bacteria reduction in chronic wounds treated with plasma (regardless of the species and the level of resistance to antibiotics) compared to untreated control wounds [Isbary et al. BJD 2010, Isbary et al. BJD 2012].

- Quicker and better recovery of chronic and acute wounds [Isbary et al. CPMJ 2013,  Heinlin et al. Wound Rep. Reg. 2013]

- Faster healing of the lesions (Herpes Zoster, Hailey-Hailey and atopic eczema) [Isbary et al. Archiv. Dermatol. 2011, Isbary et al. CPMJ 2014]

- Reduction of acute pain [Isbary et al. New Microbes and New Infections 2014]

A summary of all these results can be found in the final report of the clinical trial (final report of clinical trials D  PDF).

• The plasma device ("MicroPlaSter", new name: SteriPlas) used in these clinical trials has been introduced to the market in August 2015 by our business partner and licensee - Adtec Ltd. - [Patent "MicroPlaSter - Plasma Torch" in Europe, the USA and Russia]. 

• terraplasma GmbH is pursuing the development of a new medical device for the treatment of chronic wounds with the following features: small, handy, battery-powered, no tubes or cables, no patient probes, one-handed operation, large treatment area, proven safety (through in vitro and ex vivo studies) [patent „Electrode arrangement for generating a non-thermal plasma“ in Japan; patent application „Electrode arrangement for generating a non-thermal plasma“ in EU, USA and China; patent application „Appliance for at least partially sterilizing a contaminated surface“ in USA and EU; patent application „Device and method for the plasma treatment of surfaces and use of a device“ in USA and EU; patent application „Elektrodenanordnung und Plasmaquelle zur Erzeugung eines nichtthermischen Plasmas sowie ein Verfahren zum Betreiben einer Plasmaquelle“ in Germany].




Medical technology/

Plasma device "SteriPlas"

Disinfection/sterilization of dental instruments and endoscopes

• The Surface Micro Discharge (SMD) technology facilitates the development of scalable and flexible plasma electrodes.

• In a feasibility study for disinfection/sterilisation of dental instruments we developed a functional model consisting of several cylindrical SMD electrodes.

• By pumping the air and plasma species produced by the electrode through the fine channels and cavities of the instruments, these could be disinfected, respectively sterilised.

• The validation of this method was confirmed by certified, external service providers. The results showed a reduction of Enterococcus faecium to 99.9999% in the fine channels and cavities of different dental instruments.




Medical technology/


Sterilisation of thermolabile equipment

• Based on the Surface Micro Discharge technology large and also encapsulated plasma electrodes can be developed.

• terraplasma GmbH designed a functional prototype to demonstrate that sterilisation – i.e. a reduction of e.g. Geobacillus stearothermophilus to 99.9999% - is feasible even within a short treatment period of less than 5 min.

• Studies regarding the scalability demonstrate that the development of big chambers with large electrodes for sterilizing larger thermolabile equipment is feasible.

Medical technology/